Salt Formation Stability Study and Tablet Formulation of Mefenamic Acid with Improved Drug Dissolution

Mefenamic acid is characterized by a low oral bioavailability due to its slow dissolution and absorption. The purpose of this study was investigate the effect salt formation on mefenamic physical stability. Potassium, sodium lysine salts were prepared. resulting formed scanning electron microscopy, hot-stage Fourier transform infrared spectroscopy, differential calorimetry powder X-ray diffractometry. In addition, accelerated stability test performed at 45°±2° 75 %±5 % relative humidity for 3 mo. prepared evaluated in comparison untreated acid. results showed that potassium successfully prepared, while could not be same method. both significantly different, but more stable than salt. For reason, mefenamate selected formulating immediate-release tablets. It also found formulated tablets containing gave rapid drug dissolution, compared Thus, it can concluded tablet formulation improve